You should never vacuum rodent droppings in your attic because vacuuming can send contaminated particles into the air

https://ericktxzw116.silverstonebrief.com/posts/what-proper-attic-decontamination-involves-after-a-rodent-infestation

You should never vacuum rodent droppings in your attic because vacuuming can send contaminated particles into the air and raise the risk of exposure to rodent-borne diseases.